Per regulation 7.3: read the job, stamp the address.Hire clerks before the paperwork becomes structural.
Proteins arrive from the ER via the Golgi. Read the oldest protein’s function and use a destination stamp (or keys 1, 2, 3). Correct deliveries earn 10 postage and restore 1 health.
Regulation 7.3 · Keep the office open: wrong stamps cost 18 health; packages waiting over 18 seconds or arriving at a full belt cost 12. The shift ends at zero health. Arrivals accelerate every 30 seconds; there is no time limit.
Personnel and requisitions: clerks automatically tag the oldest package correctly. First hire costs 30; later hires improve speed down to 1.5 seconds. Extra belt spaces buy time. Maintenance restores 20 health. Upgrades are bought with postage; no offline earnings. Named clerks, office regulations, shift subtitles and staff remarks are fictional office humor; shift subtitles do not change the cargo mix.
Scientific address book: secreted proteins leave the cell; membrane proteins are delivered to the cell surface; selected lysosomal enzymes use mannose-6-phosphate sorting via endosomes. Not all proteins receive the same modification. Real mistargeted proteins are not universally sent for lysosomal digestion.
Pause or open this guide to freeze the simulation. Survive beyond your best time; a typical first run lasts around 1–2 minutes. Mouse, touch and keyboard work. The canvas is an illustrative Golgi and vesicle scene, not a to-scale cell.
